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For example, homozygous p53R172H knock-in mice carrying an allele for constitutively active KRas showed a selective increaseof mutant p53 levels in hyperplastic lesions in the lungs before tumor onset.Conversely, this was not observed in mice with mutant p53 without Ras activation,or mice with activated Ras in a wt p53 background [ 26].
Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ(2000) Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. The patient is placed in the prone positionon a padded operating table.
The mucus-secreting acini are readilydiscernible at this low magnification because oftheir lightstaining.
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Randomly synthesizedcompounds can be tested for a variety of pharmacologicalactivities. National Institutes ofHealth, among others, provides guidance regarding the humane care and use of laboratoryanimals.
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